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Hofmann elimination, also known as exhaustive methylation, is a process where a tertiary amine is reacted to create a quaternary amine salt and an alkene by treatment with excess methyl iodide followed by treatment with silver oxide, water, and heat. : After the first step, a quaternary ammonium iodide salt is created. After replacement of iodine by an hydroxyl anion, an elimination reaction takes place to the alkene. With asymmetrical amines, the major alkene product is the least substituted and generally the least stable, an observation known as the Hofmann rule. This is in direct contrast to normal elimination reactions where the more substituted, stable product is dominant (Zaitsev's rule). The reaction is named after its discoverer, August Wilhelm von Hofmann. An example is the synthesis of trans-cyclooctene: : In a related chemical test called Herzig–Meyer alkimide group determination a tertiary amine with at least one methyl group and lacking a beta-proton is allowed to react with hydrogen iodide to the quaternary ammonium salt which when heated degrades to iodomethane and the secondary amine. == See also == * Hofmann rearrangement * Emde degradation 抄文引用元・出典: フリー百科事典『 ウィキペディア（Wikipedia）』 ■ウィキペディアで「Hofmann elimination」の詳細全文を読む スポンサード リンク
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